বৃহস্পতিবার, ৩ জানুয়ারী, ২০১৩

New information on autism and genetics

Jan. 3, 2013 ? Research out of the George Washington University (GW), published in the journal Proceedings of the National Academy of Sciences (PNAS), reveals another piece of the puzzle in a genetic developmental disorder that causes behavioral diseases such as autism. Anthony-Samuel LaMantia, Ph.D., professor of pharmacology and physiology at the GW School of Medicine and Health Sciences (SMHS) and director of the GW Institute for Neuroscience, along with post-doctoral fellow Daniel Meechan, Ph.D. and Thomas Maynard, Ph.D., associate research professor of pharmacology and physiology at GW SMHS, authored the study titled "Cxcr4 regulation of interneuron migration is disrupted in 22q11.2 deletion syndrome."

For the past nine years, LaMantia and his colleagues have been investigating how behavioral disorders such as autism, attention deficit hyperactivity disorder (ADHD), and schizophrenia arise during early brain development. His work published in PNAS focuses specifically on the effects diminished 22q11.2 gene dosage has on cortical circuit development.

This research shows for the first time that genetic lesions known to be associated with autism and other behavioral diseases disrupt cellular and molecular mechanisms that ensure normal development of a key type of cortical neuron: the interneuron. LaMantia and his colleagues had found previously that one type of cortical neuron, the projection neuron, is not generated in appropriate numbers during development in a mouse model of 22q11 Deletion Syndrome. In the current study published in PNAS, LaMantia found that interneurons, while made in the right numbers at their birthplace outside of the cortex, are not able to move properly into the cortex where they are needed to control cortical circuit activity. The research shows that the main reason they don't move properly is due to diminished expression of activity of a key regulatory pathway for migration, the Cxcr4 cytokine receptor.

"This gives us two pieces of the puzzle for this genetic developmental disorder," said LaMantia. "These two pieces tell us that in very early development, those with 22q11.2 deletion syndrome do not make enough cells in one case, and do not put the other cells in the right place. This occurs not because of some degenerative change, but because the mechanisms that make these cells and put them in the right place during the first step of development have gone awry due to mutation."

The next step in LaMantia's research is to probe further into the molecular mechanisms that disrupt the proliferation of projection neurons and migration of interneurons. "If we understand that better and understand its consequences, we can go about fixing it," said LaMantia. "We want to understand why cortical circuits don't get built properly due to the genetic deletion of chromosome 22."

LaMantia recently received the latest installment of a 10-year RO1 grant from the National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health & Human Development for his project, titled "Regulation of 22q11 Genes in Embryonic and Adult Forebrain." This will allow him to further his research.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by George Washington University, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. T. M. Maynard, G. T. Haskell, A. Z. Peters, L. Sikich, J. A. Lieberman, and A.-S. LaMantia. A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proceedings of the National Academy of Sciences, 2003; 100 (24): 14433 DOI: 10.1073/pnas.2235651100

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/BlY-NP8PT5w/130103113850.htm

giants vs 49ers san francisco 49ers san francisco 49ers sf 49ers joe paterno died 49ers game ravens

Coalition of nuns, evangelical Catholic group back Illinois gay ...

nunsSPRINGFIELD, Ill. ? Sister Donna Quinn, a Chicago native who has been a Catholic nun for over 50 years, said it?s about time for Illinois to approve legislation that would legalize same-sex marriage.

?We believe in this, this has to be done,? she said. ?We can do nothing less.?

Quinn, the coordinator of the National Coalition of American Nuns, which comprises over 2,000 nuns from across the country, said giving gay and lesbian couples the right to marry is about fairness and respecting the love of people in committed relationships.

?It?s more of a belief in people, in all people, gay and lesbian and ? it doesn?t matter,? said Quinn. ?Their choice to marry is important and the benefits are crucial for their living, their livelihood, and the children they raise.?

Quinn and other members of the local faith community have thrown their support behind the Religious Freedom and Marriage Fairness Act, a bill that could potentially see a vote in the Illinois Senate as early as Thursday and in the Illinois House as early as Sunday or Monday.

?I think the support from the religious community is heartwarming,? said Rick Garcia, longtime LGBT rights activist and director of the Equal Marriage Project at The Civil Rights Agenda. ?It?s critical. It?s critical to counter the anti-gay fundamentalists and Catholic bishops.?

Quinn and several religious leaders are condemning recent comments by Chicago Cardinal Francis George of the Roman Catholic Church, in which he said same-sex marriage violates natural law because gay and lesbian couples cannot produce children. George sent a pastoral letter to local Catholic priests, urging them to lobby against the bill.

?Civil laws that establish ?same sex marriage? create a legal fiction,? George wrote, ?The State has no power to create something that nature itself tells us is impossible.?

This comes in contrast to results of a recent poll?conducted by the Paul Simon Public Policy Institute at Southern Illinois University released in late September that shows a majority of Illinois Catholics approve of legally recognized same-sex unions.

Eighty-one percent of Catholics surveyed support either full marriage equality for gay and lesbian couples or the right to a civil union. Specifically, 39.9 percent said they support marriage rights and 40.1 percent said their position is for same-sex couples to have civil unions. Only 15.7 percent said there should be no legal recognition of same-sex relationships,?according to the poll.

The numbers suggest that Catholics, too, are part of the growing wave of support for the bill, and others in the faith community won?t let George?s calls against it go unchallenged.

Bishop Alan Wilkowski of the Evangelical Catholic Diocese of the Northwest issued his own letter Wednesday to lawmakers and made direct phone calls to some, urging them to support the bill and debunk ?the myths advocated in the Cardinal?s letter,? he said.

?Based on our baptismal promise, I think that as men an women of faith, we have a right and obligation to enhance and protect the civil and human rights of all people,? Wilkowski said. ?When religious communities ? when they recognize their obligation as stewards of God?s creating ? we have to do everything possible to improve the lives of all people. We cannot sit by silently and let people get relegated to less than equal status than other people.

Wilkowski argues that George is overstepping Catholic teachings, as well as the concept of an individual?s internal forum, by demanding government policy match the rules of his church, he said.

?We don?t live in a theocracy,? the Bishop said. ?For the Cardinal to state that because of Roman Catholic ecclesiology, civil law must mirror that ? that is voicing their beliefs on every man and woman in this state.?

However, Wilkowski believes the Cardinal and the Roman Catholic Church have the right to their own beliefs.

?If Rome wishes to limit marriage to just heterosexual couples, they can do that,? he said.

In addition, Wilkowski explains in his letter that marriage has been through several evolutions since the beginning of mankind and that it should no longer be attached to procreating.

?There?s never been a set concept of what marriage is.?If we go back to before christianity, marriage was simply for procreation. Men had wives, it was simply for the purpose of procuring male offspring. That was considered the norm for centuries,??he told?Chicago Phoenix.

?The Cardinal?s letter insults the intelligence of men and women by reducing natural law to some sort of circus acrobatic act,? he said, referring to sex for procreation. ?The vocation of marriage is more than what one does in the bedroom. It is how two people come together, sharing their faith and the holy spirit in their lives. What do they do to build up the kingdom of God on earth.?

Both Quinn and Wilkowski are optimistic about the bill?s chances in the General Assembly but point out that the Catholic Church is pouring a lot of money into the same-sex marriage debate here.

?A lot of money is spent by leaders in the Catholic community against this issue,? Quinn said. ?I don?t think that is as well known as other issues. When so much money is spent against women, marriage equality, reproductive justice ? these are issues that when Catholic money is thrown to lobby against it, people need to rise up against it in protest.?

They praise people throughout the religious community and elsewhere for supporting the bill.

?I just feel very hopeful for this movement,? Quinn said.

Source: http://chicagophoenix.com/2013/01/02/coalition-of-nuns-evangelical-catholic-group-back-illinois-gay-marriage-bill/

young jeezy world wildlife fund gsa keith olbermann andrew bynum the time machine michelin tires

বুধবার, ২ জানুয়ারী, ২০১৩

Tool to evaluate genome sequencing method developed

Jan. 2, 2013 ? Advances in bio-technologies and computer software have helped make genome sequencing much more common than in the past. But still in question are both the accuracy of different sequencing methods and the best ways to evaluate these efforts. Now, computer scientists have devised a tool to better measure the validity of genome sequencing.

The method, which is described in the journal PLOS One, allows for the evaluation of a wide range of genome sequencing procedures by tracking a small group of key statistical features in the basic structure of the assembled genome. Such sequence-assembly algorithm lays out the individual short reads (strings of DNA's four nucleic acid bases sampled from the target genome) to put together the complete genome sequence -- much like a complex jig-saw puzzle. The method uses techniques from statistical inference and learning theory to select the most significant features. Surprisingly, the method concludes that many features thought by human experts to be the most important were actually highly misleading.

The work was conducted by researchers at New York University's Courant Institute of Mathematical Sciences, NYU School of Medicine, Sweden's KTH Royal Institute of Technology, and Cold Spring Harbor Laboratory.

Current evaluation methods of genome sequencing are typically imprecise. They rely on what amounts to "crowd sourcing," with scientists weighing in on the accuracy of a sequencing method. Other evaluations use apples-to-oranges comparisons in making assessments, thus limiting their value.

In the PLOS One work, the researchers expanded upon an earlier system they created, Feature Response Curve (FRCurve), which offers a global picture of how genome-sequencing methods, or assemblers, are able to deal with different regions and different structures in a large complex genome. Specifically, it points out how an assembler might have traded off one kind of quality measure at the expense of another kind. For instance, it shows how aggressively a genome assembler might have tried to pull together a group of genes into a contiguous piece of the genome, while incorrectly rearranging their correct order and copy numbers.

However, FRCurve has a significant limitation -- it can only gauge the accuracy of certain kinds of assemblers at one time, thereby excluding comparisons among the range of sequencing methods currently being employed. Many of these methods, where the original FRCurve failed, are becoming highly popular, as they are specifically designed to work with the most established next-generation sequencing technologies and are able to perform some error correction and data compression. However, by doing so, they also discard the original signature of key statistical features (e.g., position and orientation of the reads used to generate the candidate sequence) that FRCurve needs for evaluation.

The work reported in PLOS One unveils a new method, FRCbam, which has the capability to evaluate a much wider class of assemblers. It does so by reverse engineering the latent structures that were obscured by error-correction and data compression; and it performs this operation rapidly by using efficient and scalable mapping algorithms.

Instead of assumption-ridden simulation or expensive auxiliary methods, FRCbam validates its analysis by examining a large ensemble of assemblers working on a large ensemble of genomes, selected from crowd-sourced competitions like GAGE and Assemblathons. This way, FRCbam can characterize the statistics that are expected and then validate any individual system with respect to it.

FRCbam and FRCurve are expected to be used routinely to rank and evaluate future genome projects. This method is currently employed to evaluate the sequence assembly of the Norway Spruce, one of the largest genomes sequenced so far -- it is seven times longer than the human genome.

The study's authors were: Francesco Vezzi, a postdoctoral researcher in the School of Computer Science and Communication at Sweden's KTH Royal Institute of Technology, Science for Life Laboratory; Giuseppe Narzisi, a researcher at Cold Spring Harbor Laboratory's Simons Center for Quantitative Biology; and Bud Mishra, a professor at NYU's Courant Institute of Mathematical Sciences who also holds appointments at Cold Spring Harbor Laboratory and NYU School of Medicine.

The study was supported by grants from Knut and Alice Wallenberg Foundation and the National Science Foundation (CCF-0836649 and CCF-0926166).

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by New York University, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Francesco Vezzi, Giuseppe Narzisi, Bud Mishra. Reevaluating Assembly Evaluations with Feature Response Curves: GAGE and Assemblathons. PLoS ONE, 2012; 7 (12): e52210 DOI: 10.1371/journal.pone.0052210

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Hge_kDEyl7Q/130102104551.htm

a star is born oscar nominees oscar nominations 2012 kombucha tea separation of church and state dale earnhardt oscar predictions

NHL, players' union set to meet at league offices

FILE - This Aug. 14, 2012, file photo shows NHL commissioner Gary Bettman, left, and Bill Daly, deputy commissioner and chief legal officer, following collective bargaining talks in Toronto. The NHL is set to get back to the bargaining table Sunday, Dec. 30, 2012, with the locked-out players? association after a new contract offer from the league broke the ice between the fighting sides. "We delivered to the union a new, comprehensive proposal for a successor CBA," NHL deputy commissioner Bill Daly said in a statement Friday, Dec. 28. "We are not prepared to discuss the details of our proposal at this time." (AP Photo/The Canadian Press, Chris Young, File)

FILE - This Aug. 14, 2012, file photo shows NHL commissioner Gary Bettman, left, and Bill Daly, deputy commissioner and chief legal officer, following collective bargaining talks in Toronto. The NHL is set to get back to the bargaining table Sunday, Dec. 30, 2012, with the locked-out players? association after a new contract offer from the league broke the ice between the fighting sides. "We delivered to the union a new, comprehensive proposal for a successor CBA," NHL deputy commissioner Bill Daly said in a statement Friday, Dec. 28. "We are not prepared to discuss the details of our proposal at this time." (AP Photo/The Canadian Press, Chris Young, File)

FILE - In this Dec. 6, 2012, file photo, NHL Commissioner Gary Bettman, right, and deputy commissioner Bill Daly speak to reporters in New York. The NHL made a new proposal to the players' association, hoping to spark talks to end the long lockout and save the hockey season. Daly said Friday, Dec. 28, 2012, the league made its offer Thursday and was waiting for a response. (AP Photo/Mary Altaffer, File)

(AP) ? The NHL and the union are back at the bargaining table and seem determined to work toward a deal to save the hockey season.

A full day of talks was planned for Tuesday, one day after negotiations resumed following nearly three weeks apart. On Monday, the players' association presented a counterproposal to an offer made by the league late last week. The NHL spent Monday night reviewing the document, then got together again with the union Tuesday.

Small groups from each side met and conferred by conference calls all afternoon about provisions of a potential collective bargaining agreement. A full meeting of the negotiating teams wasn't expected at the league office before 6:30 or 7 p.m. EST, a union spokesman said. The NHL then requested that the meeting be pushed back to 9 p.m.

What is clear is that time has become a real factor.

"We've said we need to drop the puck by Jan. 19 if we're going to play a 48-game season," Commissioner Gary Bettman said. "We don't think it makes sense to play a season any shorter than that."

That leaves a little less than two weeks to reach an agreement and hold one week of training camp before starting the season. All games through Jan. 14 have been canceled, claiming more than 50 percent of the original schedule.

The NHL is the only North American professional sports league to cancel a season because of a labor dispute, losing the 2004-05 campaign to a lockout. A 48-game season was played in 1995 after a lockout stretched into January.

The NHL was supposed to be celebrating its annual outdoor Winter Classic between the Toronto Maple Leafs and Detroit Red Wings on Tuesday ? the 108th day of the lockout ? at Michigan Stadium. But that game was canceled long ago along with the All-Star game.

Monday's talks marked the first time the NHL and union met in person since Dec. 13. Bettman says a deal must be reached by Jan. 11 so the season can begin eight days later.

When the sides met Monday, the union brought a condensed counterproposal in response to the NHL's 288-page contract offer. There were some discussions between the negotiators and some time spent apart in internal meetings.

Neither side would elaborate on what was offered in either proposal or characterize any of Monday's discussions that union executive director Donald Fehr said "weren't terribly long."

"There was an opportunity for the players to highlight the areas they thought we should focus on based on their response, and that's something we've got to look at very closely in addition to the myriad of other issues," Bettman said. "The process continues and we're anticipating getting back together."

That neither offer was quickly dismissed could be taken as a positive sign that perhaps the gap has narrowed.

"I'm out of the prediction business," Fehr said. "You get up every day and you try to figure out how to make an agreement that day, and if it fails you try and do it the next day. That's exactly where we are."

Bettman also reserved judgment when asked if progress was made.

"I think it would be premature for me to characterize it and not particularly helpful to the process," he said.

It is still possible this dispute eventually could be settled in the courts if the sides can't reach a deal on their own.

The NHL filed a class-action suit this month in U.S. District Court in New York in an effort to show its lockout is legal. In a separate move, the league filed an unfair labor practice charge with the National Labor Relations Board, contending bad-faith bargaining by the union.

Those moves were made because the players' association took steps toward potentially declaring a "disclaimer of interest," which would dissolve the union and make it a trade association. That would allow players to file antitrust lawsuits against the NHL.

Union members voted overwhelmingly to give their board the power to file the disclaimer by Wednesday. If that deadline passes, another authorization vote could be held to approve a later filing.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-01-01-NHL%20Labor/id-cf24696c8f924c89aa59d03affaf9b71

papa johns guacamole recipe ufc 143 results kickoff time super bowl 2012 superbowl national anthem patriots vs giants super bowl superbowl halftime show

Saving Pets ? Blog Archive ? Cats who matter & those who don't ...

For many years I have been trapping cats and giving them to (WA cat welfare organisation ? name removed). I have been paying for the surgeries and have done so for many cats and they have been returned to the place where they were living.

(WA cat welfare organisation) have now told me they will not sterilise cats unless they are going to rehome them, citing the West Australian Cat Act 2011 as a reason for this.

Cats that are positive for FeLV or FIV, or cats that are just too wild to be rehomed are now being euthanased instead of being returned, even though the cats have people that are feeding them in a commercial setting.

Do you know if there is anything we can do?

The new WA cat laws require cats to be microchipped to a single owner, registered to an address and wear a collar. Most councils will introduce a two cat limit.

All of these details preclude TNR for cats in WA. Sadly, I am unsurprised that this group is no longer investing in desexing cats, who will likely later be rounded up by council, for falling foul of the new laws.

There are a currently indeterminable number of stray cats living in close proximity to humans in WA. This population could be as low as 100,000 or as high as 2 million. These aren?t ?ferals? but a human dependent, self-sustaining population of cats. The best hope they had for avoiding being impounding by a local council officer and killed in a pound, was cat welfare charities desexing them and supporting those people caring for them (community cat carers, industrial sites and retail & restaurant locations).

Except now ? thanks to these new laws ? these cat welfare groups are not.

The cat groups who supported these laws have thrown unowned cats under the bus, to ensure they have future funding via council contracts and animal welfare grants. For their moment in the spotlight, they?ve condemned hundreds of thousands of cats to death.

Cats who have owners matter. Cats who generate income matter.
Cats who are neither able to be adopted out, nor can be used for a publicity opportunity with the Premier ? simply don?t matter.

See also: WA Cat Laws; the truth starts to seep through the spin

Source: http://www.savingpets.com.au/2013/01/cats-who-matter-those-who-dont-the-wa-cat-laws-fallout-begins/

rick perry travis barker get back on board rob lowe peyton manning what is sopa marianne gingrich ibooks author

মঙ্গলবার, ১ জানুয়ারী, ২০১৩

House to vote: New Year's Night on the 'cliff'

House Majority Leader Eric Cantor, R-Va., left, with Speaker of the House John Boehner, R-Ohio, enters a second Republican caucus meeting at the U.S. Capitol in Washington, on Tuesday, Jan. 1, 2013. (AP Photo/Jacquelyn Martin)

House Majority Leader Eric Cantor, R-Va., left, with Speaker of the House John Boehner, R-Ohio, enters a second Republican caucus meeting at the U.S. Capitol in Washington, on Tuesday, Jan. 1, 2013. (AP Photo/Jacquelyn Martin)

A Marine sentry stands guard, indicating that President Obama is working in the West Wing of the White House, as discussions regarding the fiscal cliff continue on Capitol Hill in Washington on Tuesday, Jan. 1, 2013. (AP Photo/Charles Dharapak)

Speaker of the House John Boehner, R-Ohio, center right, and House Majority Leader Eric Cantor, R-Va., center left, walk down stairs to a second Republican conference meeting to discuss the "fiscal cliff" bill_ which was passed by the Senate Monday night_ at the Capitol in Washington, Tuesday, Jan. 1, 2013. (AP Photo/J. Scott Applewhite)

House Minority Leader Nancy Pelosi of Calif., center, flanked by Rep. Joseph Crowley, D-NY, left, and Rep. Xavier Becerra, D-Calif., gestures during a news conference on Capitol Hill in Washington, Tuesday, Jan. 1, 2013, to discuss the fiscal cliff bill passed by the Senate last night that's waiting for a vote in the Republican-controlled House. The House Democrats met earlier with Vice President Joe Biden who has been shuttling between the White House and Capitol Hill to help negotiate a legislative path to avert the across-the-board tax increases and sweeping spending cuts that could damage the economy. (AP Photo/J. Scott Applewhite)

House Speaker John Boehner Ohio walks to his office on Capitol Hill in Washington, Tuesday, Jan. 1, 2013, as legislation to negate a fiscal cliff of across-the-board tax increases and sweeping spending cuts moves to the GOP-dominated House following a bipartisan, middle-of-the-night approval in the Senate. Boehner is expected to encounter opposition from conservatives within his own party. (AP Photo/J. Scott Applewhite)

(AP) ? Maneuvered into a political corner, House Republicans abandoned demands for changes in emergency legislation to prevent widespread tax increases and painful across-the-board spending cuts and cleared the way for a final, climactic New Year's night vote.

The decision capped a day of intense political calculations for conservatives who control the House. They had to weigh their desire to cut spending against the fear that the Senate would refuse to consider any changes they made in the "fiscal cliff" bill, sending it into limbo and saddling Republicans with the blame for a whopping middle class tax increase.

Adding to the GOP discomfort, one Senate Democratic leadership aide said Majority Leader Harry Reid would "absolutely not take up the bill" if the House changed it. The aide spoke on condition of anonymity, citing a requirement to keep internal deliberations private.

The legislation cleared the Senate hours earlier on a lopsided pre-dawn vote of 89-8. Administration officials met at the White House to monitor its progress.

"I do not support the bill. We are looking, though, for the best path forward," House Majority Leader Eric Cantor, R-Va., declared after one meeting of the party's rank-and-file.

Despite Cantor's remarks, Speaker John Boehner took no public position on the bill as he sought to negotiate a conclusion to the final crisis of a two-year term full of them.

It wasn't the first time that the tea party-infused House Republican majority has rebelled against the party establishment since the GOP took control of the chamber 24 months ago. But with the two-year term set to end Thursday at noon, it was likely the last. And as was true in earlier cases of a threatened default and government shutdown, the brinkmanship came on a matter of economic urgency, leaving the party open to a public backlash if tax increases do take effect on tens of millions.

After intensive deliberations ? a pair of rank-and-file meetings sandwiched around a leadership session, the GOP high command had not yet settled on a course of action by early evening.

Instead, they canvassed Republicans to see if they wanted simply to vote on the Senate measure, or whether they wanted first to try and add spending cuts totaling about $300 billion over a decade. The cuts had passed the House twice earlier in the year but are opposed by most if not all Senate Democrats.

"We've gone as far as we can go," said Rep. Jack Kingston, R-Ga. "I think people are ready to bring this to a conclusion, and know we have a whole year ahead of us" for additional fights over spending.

The economic as well as political stakes were considerable.

Economists have warned that without action by Congress, the tax increases and spending cuts that technically took effect with the turn of the new year at midnight could send the economy into recession.

Even with enactment of the legislation, taxes are on the rise for millions.

A 2 percentage point temporary cut in the payroll tax, originally enacted two years ago to stimulate the economy, expired with the end of 2012. Neither Obama nor Republicans have made a significant effort to extend it.

The Senate-passed bill was designed to prevent that while providing for tax increases at upper incomes, as Obama campaigned for in his successful bid for a second term.

It would also prevent an expiration of extended unemployment benefits for an estimated two million jobless, block a 27 percent cut in fees for doctors who treat Medicare patients, stop a $900 pay increase for lawmakers from taking effect in March and head off a threatened spike in milk prices.

At the same time, it would stop $24 billion in spending cuts set to take effect over the next two months, although only about half of that total would be offset with spending reductions elsewhere in the budget.

The non-partisan Congressional Budget Office said the measure would add nearly $4 trillion over a decade to federal deficits, a calculation that assumed taxes would otherwise have risen on taxpayers at all income levels. There was little or no evident concern among Republicans on that point, presumably because of their belief that tax cuts pay for themselves by expanding economic growth and do not cause deficits to rise.

The relative paucity of spending cuts was a sticking point with many House Republicans. Among other items, the extension of unemployment benefits costs $30 billion, and is not offset by savings elsewhere.

"I personally hate it," said Rep. John Campbell of California. "The speaker the day after the election said we would give on taxes and we have. But we wanted spending cuts. This bill has spending increases. Are you kidding me? So we get tax increases and spending increases? Come on."

Others said unhappiness over spending outweighed fears that the financial markets will plunge on Wednesday if the fiscal cliff hasn't been averted.

"There's a concern about the markets, but there's a bigger concern, which is getting this right, which is something we haven't been very good at over the past two years," said Rep. Steve LaTourette of Ohio.

House Democrats met privately with Biden for their review of the measure, and the party's leader, Rep. Nancy Pelosi of California, said afterward that Boehner should permit a vote.

"That is what we expect. That is what the American people deserve," she said.

For all the struggle involved in the legislation, even its passage would merely clear the way for another round of controversy almost as soon as the new Congress convenes.

With the Treasury expected to need an expansion in borrowing authority by early spring, and funding authority for most government programs set to expire in late March, Republicans have made it clear they intend to use those events as leverage with the administration to win savings from Medicare and other government benefit programs.

McConnell said as much moments before the 2 a.m. Tuesday vote in the Senate ? two hours after the advertised "cliff" deadline.

"We've taken care of the revenue side of this debate. Now it's time to get serious about reducing Washington's out-of-control spending," he said. "That's a debate the American people want. It's the debate we'll have next. And it's a debate Republicans are ready for."

The 89-8 vote in the Senate was unexpectedly lopsided.

Despite grumbling from liberals that Obama had given way too much in the bargaining, only three Democrats opposed the measure.

Among the Republican supporters were Sen. Pat Toomey of Pennsylvania, an ardent opponent of tax increases, as well as Sen. Ron Johnson of Wisconsin, elected to his seat two years ago with tea party support.

It marked the first time in two decades that Republicans willingly supported higher taxes, in this case on incomes over $400,000 for individuals and $450,000 for couples. Taxes also would rise on estates greater than $5 million in size, and on capital gains and dividend income made by the wealthy.

___

Associated Press writers Andrew Taylor, Larry Margasak and Julie Pace contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-01-01-Fiscal%20Cliff/id-92efa7ff7e674bd99e2ae769f130c8c6

haywire dog the bounty hunter tacoma narrows bridge weather nyc open marriage department of justice doj

Bicosoeca -- flagellate in a wineglass


ShareShare ?ShareEmail ?PrintPrint



Last post of 2012! Hope it was a good year for you all, and that the next will be even better ? Happy New Year! Some protists sitting in champagne glasses might be relevant to our interests:

Bicosoecids are non-photosynthetic relatives of brown algae. Usually nestled in a delicate lorica (but sometimes devoid of one), bicosoecids sit attached to a substrate with one flagellum, and wave around the other to bring in bacterial prey to devour. At the base of the flagella is a lip-like structure where the unfortunate prey get engulfed after travelling down the current.?When startled, they rapidly withdraw their flagellum into a characteristic spiral, which you can see in the bottom specimen of the group. Most tend to be solitary, but this species forms loricate tree-like colonies, like wineglasses stacked upon each other. Despite their small size and timid appearance, their cell structure is fairly complicated and ?hoping you?d agree with me ? quite elegant.

Psi WavefunctionAbout the Author: Psi Wavefunction is a recent graduate of the University of British Columbia working as a researcher at Indiana University, Bloomington, and blogs about protists and evolution at The Ocelloid as well as at Skeptic Wonder. Follow on Twitter @Ocelloid.

The views expressed are those of the author and are not necessarily those of Scientific American.

Source: http://rss.sciam.com/click.phdo?i=9d11f2d074a47f333a5b3baf444bd91b

Marissa Mayer Jon Lord Colorado shootings dark knight rises Aurora shooting James Eagan Holmes jeremy lin